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The role of creatine supplementation and mTORC1 signaling in ameliorating cognitive deficiency in a neuroinflammatory rat model
(University of Missouri--Columbia, 2022)
proteins, PSD-95 and synapsin, in dentate gyrus but not in medial prefrontal cortex. Immunohistochemistry analysis revealed upregulation of mTORC1 in NeuN+ neurons. Importantly, selective inhibition of mTORC1 signaling through rapamycin attenuated...
The effects of heat stress and feed restriction on the microbiome of lactating dairy cows
(University of Missouri--Columbia, 2020)
stress on one group of cows (n = 6) in a time course design through pretreatment, heat stress, and recovery periods. Our second study evaluated the effects of elevated and clamped rectal temperature (40[degrees]C [plus-minus] 0.5; n = 6) or pair...
Ventricle-specific fibrotic cardiac remodeling in the progression of heart failure with preserved ejection fraction
(University of Missouri--Columbia, 2022)
Heart failure with preserved ejection fraction (HFpEF) is currently the most prominent form of heart failure (HF). Despite the rising prevalence over the last few years, the pathogenesis of this disease is still unknown. ...